Binaphthyl-prolinol chiral ligands: design and their application in enantioselective arylation of aromatic aldehydes.
Chao YaoYaoqi ChenRuize SunChao WangYue HuangLin LiYue-Ming LiPublished in: Organic & biomolecular chemistry (2022)
Binaphthyl-prolinol ligands were designed and applied in enantioselective arylation of aromatic aldehydes and sequential arylation-lactonization of methyl 2-formylbenzoate. Under optimized conditions, the reactions provided the desired diarylmethanols and 3-aryl phthalides in up to 96% yields with up to 99% ee and up to 89% yields with up to 99% ee, respectively. In particular, essentially optically pure 3-aryl phthalides (over 99% ee) were obtained in large quantities through recrystallization.