Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.
Min FanTing WangLi-Yan PengJun-Shang HuangXing-De WuHe-Yao WangQin-Shi ZhaoPublished in: Chemistry & biodiversity (2021)
A new neo-clerodane diterpenoid, salvihispin H (1), and six known ones (2-7) were identified from the aerial parts of Salvia hispanica L. The structure and absolute configuration of 1 were elucidated by extensive analysis of spectroscopic (1 H, 13 C, and 2D NMR, and HR-ESI-MS) and single-crystal X-ray diffraction data. The anti-diabetic effects of salvihispin H (1) and salvifaricin (2) were evaluated in diabetic db/db mice. The data showed that 1 and 2 could significantly reduce fasting blood glucose level and improve insulin resistance, and compound 1 exerted glucose-lowering effect more quickly than metformin. In addition, 1 and 2 could also reduce serum TG level in db/db mice. These results demonstrated that compounds 1 and 2 could be considered as potent candidates for the therapy of type 2 diabetes mellitus (T2DM).
Keyphrases
- blood glucose
- glycemic control
- insulin resistance
- high fat diet induced
- type diabetes
- ms ms
- electronic health record
- high resolution
- blood pressure
- big data
- wound healing
- metabolic syndrome
- adipose tissue
- mass spectrometry
- multiple sclerosis
- molecular docking
- high fat diet
- solid state
- machine learning
- cell therapy
- stem cells
- smoking cessation
- bone marrow
- wild type