Multiple adverse outcomes associated with antipsychotic use in people with dementia: population based matched cohort study.
Pearl L H MokMatthew J CarrBruce GuthrieDaniel R MoralesAziz SheikhRachel A ElliottElizabeth M CamachoTjeerd van StaaAnthony J AveryDarren M AshcroftPublished in: BMJ (Clinical research ed.) (2024)
Antipsychotic use compared with non-use in adults with dementia was associated with increased risks of stroke, venous thromboembolism, myocardial infarction, heart failure, fracture, pneumonia, and acute kidney injury, but not ventricular arrhythmia. The range of adverse outcomes was wider than previously highlighted in regulatory alerts, with the highest risks soon after initiation of treatment.
Keyphrases
- heart failure
- venous thromboembolism
- acute kidney injury
- left ventricular
- atrial fibrillation
- human health
- catheter ablation
- mild cognitive impairment
- direct oral anticoagulants
- cognitive impairment
- transcription factor
- risk assessment
- acute heart failure
- cardiac resynchronization therapy
- climate change
- combination therapy
- replacement therapy
- extracorporeal membrane oxygenation