SLC39A8 missense variant is associated with Crohn's disease but does not have a major impact on gut microbiome composition in healthy subjects.

Valerie CollijFloris ImhannArnau Vich VilaJingyuan FuGerard DijkstraEleonora A M FestenMichiel D VoskuilMark J DalyRamnik J XavierCisca WijmengaAlexandra ZhernakovaRinse K Weersma

Published in: PloS one (2019)

We could confirm the genetic association of the SLC39A8 [Thr]391 risk allele with Crohn's disease but we could only limited replicate the association in gut microbiome composition. Independent replication of gene-microbiome studies is warranted to identify true biological mechanisms.

Keyphrases

genome wide
copy number

gene expression
dna methylation

autism spectrum disorder

transcription factor