Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease.

Lisa S RobisonOlivia J GannonAbigail E SalineroCharly Abi-GhanemRichard D KellyDavid A RiccioFebronia M MansourKristen L Zuloaga

Published in: Biology of sex differences (2023)

These findings provide additional evidence for sex-dependent effects of AD pathology on energy and glucose homeostasis, which may be linked to hypothalamic inflammation.

Keyphrases

mouse model
oxidative stress
cognitive decline
type diabetes
metabolic syndrome
skeletal muscle
mild cognitive impairment
weight loss