Cell death mechanisms involved in cell injury caused by SARS-CoV-2.
Maríllya Morais da SilvaAndré Silva Lira de LucenaSergio de Sá Leitão Paiva JúniorVanessa Mylenna Florêncio De CarvalhoPriscilla Stela Santana de OliveiraMichelle Melgarejo da RosaMoacyr Jesus Barreto de Melo RegoMaira Galdino da Rocha PittaMichelly Cristiny PereiraPublished in: Reviews in medical virology (2021)
Coronavirus disease 2019 (Covid-19) is an emerging novel respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that rapidly spread worldwide. In addition to lung injury, Covid-19 patients may develop extrapulmonary symptoms, including cardiac, liver, kidney, digestive tract, and neurological injuries. Angiotensin converting enzyme 2 is the major receptor for the entry of SARS-CoV-2 into host cells. The specific mechanisms that lead to cell death in different tissues during infection by SARS-CoV-2 remains unknown. Based on data of the previous human coronavirus SARS-CoV together with information about SARS-CoV-2, this review provides a summary of the mechanisms involved in cell death, including apoptosis, autophagy, and necrosis, provoked by severe acute respiratory syndrome coronavirus.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- cell death
- cell cycle arrest
- coronavirus disease
- angiotensin converting enzyme
- endoplasmic reticulum stress
- induced apoptosis
- oxidative stress
- infectious diseases
- endothelial cells
- stem cells
- pi k akt
- angiotensin ii
- gene expression
- bone marrow
- cell proliferation
- electronic health record
- health information
- single cell
- social media
- subarachnoid hemorrhage
- binding protein
- data analysis
- machine learning