Synthetic G protein-coupled bile acid receptor agonists and bile acids act via basolateral receptors in ileal and colonic mucosa.

Iain R ToughThue W SchwartzHelen M Cox

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)

We conclude that several different targets within the lamina propria express GPBA, including L cells (that release PYY and GLP-1), enterochromaffin cells and neurons (that release 5-HT), and other enteric neurons. Furthermore, luminal-conjugated BAs require transport across the epithelium via ASBT in order to activate basolateral GPBA.

Keyphrases

induced apoptosis
cell cycle arrest
spinal cord
endoplasmic reticulum stress
signaling pathway
oxidative stress
spinal cord injury
pi k akt
ulcerative colitis