The selective orexin-2 receptor antagonist seltorexant improves sleep: An exploratory double-blind, placebo controlled, crossover study in antidepressant-treated major depressive disorder patients with persistent insomnia.
Sander BrooksGabriël E JacobsPeter De BoerJustine M KentLuc Van NuetenGuido van AmerongenRob ZuikerIva KezicRemy LuthringerPeter D van der ArkJoop Ma van GervenWayne DrevetsPublished in: Journal of psychopharmacology (Oxford, England) (2019)
Seltorexant showed a statistically significant, dose-dependent decrease in latency to persistent sleep, and increase in total sleep time and sleep efficiency combined with a tendency toward subjectively improved mood.