Horizontal fissuring at the osteochondral interface: a novel and unique pathological feature in patients with obesity-related osteoarthritis.

Lianzhi ChenFelix YaoTao WangGuangyi LiPeilin ChenMax BulsaraJessica Jun Yi ZhengEuphemie Landao-BassongaMarty FirthPraveen VasantharaoYigang HuangMichelle LorimerStephen GravesJunjie GaoRichard Carey-SmithJohn PapadimitriouChangqing ZhangDavid WoodChristopher JonesMing-Hao Zheng

Published in: Annals of the rheumatic diseases (2020)

The key pathological feature in OA patients with obesity is horizontal fissuring at the osteochondral unit interface. Obesity is strongly associated with a younger age of first TKR, which may be a result of horizontal fissures.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
machine learning
deep learning
rheumatoid arthritis
physical activity