Cardiac effects and clinical applications of MG53.
Weina ZhongDathe Z Benissan-MessanJianjie MaChuanxi CaiPeter H U LeePublished in: Cell & bioscience (2021)
Heart disease remains the leading cause of mortality globally, so further investigation is required to identify its underlying mechanisms and potential targets for treatment and prevention. Mitsugumin 53 (MG53), also known as TRIM72, is a TRIM family protein that was found to be involved in cell membrane repair and primarily found in striated muscle. Its role in skeletal muscle regeneration and myogenesis has been well documented. However, accumulating evidence suggests that MG53 has a potentially protective role in heart tissue, including in ischemia/reperfusion injury of the heart, cardiomyocyte membrane injury repair, and atrial fibrosis. This review summarizes the regulatory role of MG53 in cardiac tissues, current debates regarding MG53 in diabetes and diabetic cardiomyopathy, as well as highlights potential clinical applications of MG53 in treating cardiac pathologies.
Keyphrases
- skeletal muscle
- left ventricular
- heart failure
- type diabetes
- ischemia reperfusion injury
- atrial fibrillation
- stem cells
- gene expression
- insulin resistance
- adipose tissue
- human health
- risk factors
- cardiovascular events
- left atrial
- glycemic control
- risk assessment
- small molecule
- angiotensin ii
- binding protein
- smoking cessation
- combination therapy
- wound healing