Endothelial Cell Transcription Modulation in Cerebral Aneurysms After Endovascular Flow Diversion.
Guilherme BarrosEmma FedericoPatrick FillinghamPritha ChananaNaoki KanekoYing ZhengLouis J KimMichael R LevittPublished in: Annals of biomedical engineering (2024)
Treatment of cerebral aneurysms with FDS induces significant EC gene transcription changes related to aneurysm hemodynamics in patient-specific in vitro 3D-printed models subjected to pulsatile flow. Further investigation is needed into the relationship between transcriptional change and treatment outcome.
Keyphrases
- transcription factor
- subarachnoid hemorrhage
- endothelial cells
- coronary artery
- gene expression
- cerebral ischemia
- genome wide
- copy number
- brain injury
- genome wide identification
- robot assisted
- cerebral blood flow
- minimally invasive
- combination therapy
- high glucose
- replacement therapy
- drug induced
- genome wide analysis