Cimetidine repurposed as a potential immunomodulatory agent against colorectal carcinoma: A systematic review.

Wwm GunasekaraJlaa SachindraMenikpurage Thilini MadhushikaPlgc LiyanageS Lekamwasam

Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2024)

Repurposing of existing drugs like cimetidine has a potential to offer a survival benefit by acting as an immunomodulatory agent in patients undergoing curative resection for CRC. However, the heterogeneity seen in current studies and the evolvement of adjunctive therapies for CRC warrant large-scale, well-designed prospective RCTs to establish the efficacy of cimetidine in CRC.

Keyphrases

patients undergoing
human health
single cell
climate change
prognostic factors