A pig model of chronic hepatitis E displaying persistent viremia and a downregulation of innate immune responses in the liver.
Nancy León-JanampaIgnacio CaballeroCéline BarcFrançois DarrouzainAlain MoreauThibault GuinoiseauPhilippe GataultIsabelle FleurotMickaël RiouAnne PinardJérémy PezantChristelle RossignolCatherine Gaudy-GraffinDenys BrandJulien MarletPublished in: Hepatology communications (2023)
We developed a pig model of chronic hepatitis E that reproduced the major hallmarks of this disease. This model revealed a compartmentalization of HEV genomes in the digestive tract and a downregulation of innate immune responses in the liver. These original features highlight the relevance of our model for studies of the pathogenesis of chronic hepatitis E and for validating future treatments.