Pseudomonas aeruginosa Type III Secretion System Virulotypes and Their Association with Clinical Features of Cystic Fibrosis Patients.
Edilene do Socorro Nascimento Falcão SargesYan Corrêa RodriguesIsmari Perini FurlanetoMarcos Vinicios Hino de MeloGiulia Leão da Cunha BraboKátia Cilene Machado LopesAna Judith Pires Garcia QuaresmaLuana Nepomuceno Godim Costa LimaKarla Valéria Batista LimaPublished in: Infection and drug resistance (2020)
Our findings revealed a high prevalence of the atypical exoS+/exoU+ virulotype among P. aeruginosa isolates from patients with CF, which was associated with intermittent infection and early clinical alterations, while the exoS+/exoU- virulotype was associated with chronic infection and worse clinical results. Finally, the presented data highlight the relevance of T3SS virulence markers in the clinical progression and disease severity in CF patients.
Keyphrases
- cystic fibrosis
- pseudomonas aeruginosa
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- escherichia coli
- prognostic factors
- lung function
- staphylococcus aureus
- biofilm formation
- electronic health record
- chronic obstructive pulmonary disease
- multidrug resistant
- acinetobacter baumannii
- drug resistant
- deep learning