Zinc Preconditioning Provides Cytoprotection following Iodinated Contrast Media Exposure in In Vitro Models.
Marlon Lakmal PereraJoseph IschiaDamien M BoltonArthur ShulkesGraham S BaldwinOneel PatelPublished in: Contrast media & molecular imaging (2021)
Zinc preconditioning reduces oxidative stress following exposure to radiographic contrast media which in turn results in increased survival of renal cells. Translation of this in vitro finding in animal models will lay the foundation for future use of zinc preconditioning against contrast induced nephropathy.
Keyphrases
- ischemia reperfusion injury
- oxidative stress
- magnetic resonance
- induced apoptosis
- oxide nanoparticles
- diabetic rats
- cerebral ischemia
- contrast enhanced
- high glucose
- cell cycle arrest
- dna damage
- endoplasmic reticulum stress
- signaling pathway
- magnetic resonance imaging
- subarachnoid hemorrhage
- cell proliferation
- free survival
- cell death
- endothelial cells
- stress induced