Angiotensin II poses a negative regulatory effect on insulin signal transduction, increases oxidative stress, and may inhibit the transcription of insulin genes stimulated by insulin in NIT-1 cells. Meanwhile, angiotensin-(1-7) blocked these effects via MasR. These results corroborate the rising potential of the renin-angiotensin system (RAS) in treating diabetes.
Keyphrases
- angiotensin ii
- type diabetes
- induced apoptosis
- glycemic control
- angiotensin converting enzyme
- oxidative stress
- vascular smooth muscle cells
- cell cycle arrest
- endoplasmic reticulum stress
- transcription factor
- cardiovascular disease
- weight loss
- ischemia reperfusion injury
- cell proliferation
- metabolic syndrome
- adipose tissue
- human health
- genome wide identification