Ser-486/491 phosphorylation and inhibition of AMPKα activity is positively associated with Gleason score, metastasis, and castration-resistance in prostate cancer: A retrospective clinical study.

Melissa A BabcookMahmut AkgulSeunghee MargeviciusGregory T MacLennanPingfu FuRobert AbouassalySanjay Gupta

Published in: The Prostate (2018)

p-Ser-486/491 AMPKα1 /α2 is a novel marker of prostate cancer metastasis and castration-resistance. Ser-486/491 phosphokinases should be pursued as targets for metastatic and castration-resistant prostate cancer chemotherapy.

Keyphrases

prostate cancer
radical prostatectomy
protein kinase
skeletal muscle
squamous cell carcinoma
small cell lung cancer
locally advanced
rectal cancer