Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages.
Sabin BhandariRuomei LiJaione Simón-SantamaríaPeter McCourtSteinar Daae JohansenBård SmedsrødInigo Martinez-ZubiaurreKaren Kristine SørensenPublished in: BMC molecular and cell biology (2020)
Our findings support complementary and partly overlapping scavenging and immune functions of LSECs and KCs. This highlights the importance of including LSECs in studies of liver immunity, and liver clearance and toxicity of large molecule drugs and nano-formulations.