Transcriptome-based screening of intracellular pathways and angiogenesis related genes at different stages of thiram induced tibial lesions in broiler chickens.
Ali Raza JahejoDing ZhangSheng NiuRaza Ali MangiAfrasyab KhanMuhammad Farhan QadirAjab KhanHuan-Chun ChenWen-Xia TianPublished in: BMC genomics (2020)
We have found potential therapeutic genes concerned to erythrocytes and blood regulation, which regulated the angiogenesis in thiram induced TD chickens. This study also revealed the potential functions of erythrocytes. 1. Tibial dyschondroplasia (TD) in chickens were more on day 6, which started recovering on day 15. 2. The enriched pathway observed in TD chickens on day 6 was ribosome pathway, on day 15 were regulation of actin cytoskeleton and focal adhesion pathway. 3. The genes involved in the ribosome pathways was ribosomal protein L17 (RPL17). regulation of actin cytoskeleton pathway were Ras-related C3 botulinum toxin substrate 2 (RAC2), Ras-related protein Rap-1b precursor (RAP1B), ARF GTPase-activating protein (GIT1), IQ motif containing GTPase activating protein 2 (IQGAP2), Integrin alpha-v precursor (ITGAV), Integrin alpha-2 (ITGA2), Integrin beta-2 precursor (ITGB2), Integrin beta-3 precursor (ITGB3), Integrin alpha-IIb-like (ITGA5). Focal adhesion Proto-oncogene vav (Vav-like), Tyrosine-protein kinase Fyn-like (FYN).
Keyphrases
- cell migration
- cell adhesion
- botulinum toxin
- endothelial cells
- total knee arthroplasty
- signaling pathway
- heat stress
- genome wide
- protein protein
- protein kinase
- amino acid
- single cell
- drug induced
- binding protein
- gene expression
- biofilm formation
- cystic fibrosis
- escherichia coli
- risk assessment
- dna methylation
- wild type
- structural basis