Testicular tissue response following a 90-day subchronic exposure to HTP aerosols and cigarette smoke in rats.

Hongjuan WangYushan TianYaning FuShuhao MaXiaoxiao XuWenming WangFengjun LuXianmei LiPengxia FengShulei HanHuan ChenHongwei HouQingyuan HuChuan Liu

Published in: Toxicology research (2023)

These findings indicate that HTP_50 and Cig_23 induced oxidative stress in rat testes, induced inflammation and pyroptosis through the ROS/NLRP3/Caspase-1 pathway, and destroyed the integrity of thetesticular tissue structure.

Keyphrases

oxidative stress
cell death
diabetic rats
nlrp inflammasome
high glucose
hydrogen peroxide
reactive oxygen species
drug induced
water soluble
germ cell