Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans.

Danielle van KeulenMarianne G PouwerValur EmilssonLjubica Perisic MaticElsbet J PietermanUlf HedinVilmundur G GudnasonLori L JenningsKim HolmstrømBoye Schnack NielsenGerard PasterkampJan H N LindemanAlain J van GoolMaarten D Sollewijn GelpkeHans M G Princen Dennie Tempel

Published in: PloS one (2019)

Chronic OSM administration in APOE*3Leiden.CETP mice reduced atherosclerosis development. In line, higher serum OSM levels were correlated with improved post incident CHD survival probability in patients, suggesting a protective cardiovascular effect.

Keyphrases

cardiovascular disease
end stage renal disease
cognitive decline
ejection fraction
high fat diet induced
newly diagnosed
high fat diet
prognostic factors
free survival
peritoneal dialysis
type diabetes
patient reported outcomes
metabolic syndrome
patient reported