Interleukin-30 subverts prostate cancer-endothelium crosstalk by fostering angiogenesis and activating immunoregulatory and oncogenic signaling pathways.

Stefania Livia CiummoCarlo SorrentinoCristiano FieniEmma Di Carlo

Published in: Journal of experimental & clinical cancer research : CR (2023)

IL30 regulates the crosstalk between PC and EC and reshapes their transcriptional profiles, triggering angiogenic, immunoregulatory and oncogenic gene expression programs. These findings highlight the angiostatic and oncostatic efficacy of targeting IL30 to fight PC.

Keyphrases

gene expression
prostate cancer
signaling pathway
transcription factor
dna methylation
radical prostatectomy
endothelial cells
nitric oxide
cancer therapy
pi k akt
induced apoptosis
oxidative stress
endoplasmic reticulum stress