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SIV infection in sooty mangabeys does not impact survival but changes the relative frequency of the main cause of death.

Cristina CerianiBrianne BeisnerMaria CraneJoyce CohenIan N MooreDeanna A KulpaBeatrice H HahnGuido Silvestri
Published in: mBio (2024)
In this study, we demonstrate, for the first time, that the natural, non-pathogenic SIV infection of the African monkey SM has a clinical impact which is revealed in terms of main causes of mortality, which are significantly different in the infected animals as compared to the uninfected ones. Indeed, SIV-infected SMs are at higher risk of dying of infectious diseases but appear to be somewhat protected from cardiovascular causes of death. The identification of a specific pattern of mortality associated with the infection suggests that the host-pathogen interaction between SIV and the SM immune system, while non-pathogenic in nature, has a detectable impact on the overall health status of the animals.
Keyphrases
  • infectious diseases
  • cardiovascular events
  • palliative care
  • hiv infected
  • type diabetes
  • cardiovascular disease
  • coronary artery disease