Physical PEGylation Enhances The Cytotoxicity Of 5-Fluorouracil-Loaded PLGA And PCL Nanoparticles.

Abdelkader E AshourMohammad BadranAshok KumarTajamul HussainIbrahim A Alsarra Alaa Eldeen B Yassin

Published in: International journal of nanomedicine (2019)

The physical PEGylation significantly enhanced the entrapment and loading efficiencies of 5-FU into NPs formulated with PLGA and PCL. It also fostered the in vitro cytotoxicity of 5-FU-loaded NPs in both Daoy and HepG2 cells. Induction of early apoptosis was confirmed for some of the formulations.

Keyphrases

drug delivery
cancer therapy
physical activity
mental health
drug release
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
cell death
wound healing