miR-200b-mediated reversion of a spectrum of epithelial to mesenchymal transition states in recessive dystrophic epidermolysis bullosa squamous cell carcinomas.
Julia IllmerRoland ZaunerJosefina Piñón HofbauerMonika WimmerStefanie GrunerMichael AblingerJohannes BischofSonja DorferStefan HainzlVanessa ToberShir BergsonOfer SarigLiat SamuelovChristina Guttmann-GruberRuby Shalom-FeuersteinEli SprecherUlrich KollerMartin LaimerJohann W BauerVerena WallyPublished in: The British journal of dermatology (2023)
In summary, RDEB-SCCs exist in different EMT states and the level of miR-200b is indicative of how far an RDEB-SCC has gone down the EMT path. Moreover, reintroduction of miR-200b significantly reduced mesenchymal features.