Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins.

Amy P WebsterDarren PlantSimone EckerFlore ZuffereyJordana T BellAndrew FeberDirk S PaulStephan BeckAnne BartonFrances M K WilliamsJane Worthington

Published in: Genome medicine (2018)

Through genome-wide analysis of DNA methylation in disease-discordant monozygotic twins, we have identified a differentially variable DNA methylation signature, in the absence of differential methylation in rheumatoid arthritis. This finding supports the importance of epigenetic variability as an emerging component in autoimmune disorders.

Keyphrases

dna methylation
genome wide
rheumatoid arthritis
gene expression
disease activity
copy number
multiple sclerosis
gestational age
ankylosing spondylitis
interstitial lung disease
drug induced