Dynamic covalent single chain nanoparticles based on hetero Diels-Alder chemistry.

Nils Wedler-JasinskiThorsten LueckerathHatice MutluAnja S GoldmannAndreas WaltherMartina H StenzelChristopher Barner-Kowollik

Published in: Chemical communications (Cambridge, England) (2017)

We introduce the fully reversible folding of single chain nanoparticles (SCNPs) based on covalent hetero Diels-Alder (HDA) chemistry. A cyclopentadiene (Cp)-protected cyanodithioester (CDTE) monomer is designed and copolymerized with methyl methacrylate (MMA) via RAFT polymerization. The polymer chains are folded and subsequently unfolded by exploiting the reversible nature of the HDA reaction.

Keyphrases

histone deacetylase
quantum dots
drug discovery
endoplasmic reticulum stress
molecular dynamics simulations
simultaneous determination
liquid chromatography