Molecular matched targeted therapies for primary brain tumors-a single center retrospective analysis.
Anna-Luisa LugerSven KönigPatrick Felix SampHans UrbanIris DivéMichael C BurgerMartin VossKea FranzEmmanouil FokasKatharina FilipskiMelanie-Christin DemesAlbrecht StenzingerFelix SahmDavid E ReussPatrick N HarterSebastian A WagnerElke HattingenJennifer WichertConstantin LapaStefan FröhlingJoachim P SteinbachMichael W RonellenfitschPublished in: Journal of neuro-oncology (2022)
A broad range of actionable alterations was targeted with available molecular therapeutics. However, efficacy was largely observed in entities with paradigmatic oncogenic drivers, in particular with BRAF mutations. Further research on biomarker-informed molecular matched therapies is urgently necessary.