Age- and sex-dependent changes in sympathetic activity of the left ventricular apex assessed by 18F-DOPA PET imaging.
Irene A BurgerChristine LohmannMichael MesserliSusan BengsAnton Sebastian BeckerMonika MaredziakValerie TreyerAhmed HaiderMoritz SchwyzerDominik C BenzKen KuduraMichael FiechterAndreas A GiannopoulosTobias A FuchsChristoph GräniAju P PazhenkottilOliver GaemperliRonny R BuechelPhilipp A KaufmannChristian LoewePublished in: PloS one (2018)
Our study suggests that aging is related to sex-specific changes in regional cardiac sympathetic activity. Future studies will have to assess whether the increase in LV apical 18F-DOPA uptake with age in women is of pathogenic relevance for the higher susceptibility of postmenopausal women to conditions associated with increased sympathetic activity.
Keyphrases
- postmenopausal women
- left ventricular
- pet imaging
- bone mineral density
- heart failure
- acute myocardial infarction
- mitral valve
- adipose tissue
- pregnant women
- skeletal muscle
- hypertrophic cardiomyopathy
- coronary artery disease
- positron emission tomography
- percutaneous coronary intervention
- transcatheter aortic valve replacement