Elevated testicular apoptosis is associated with elevated sphingosine driven by gut microbiota in prediabetic sheep.

Yuanchao SunPeng SunYanting HuLiying ShanQi GengYutian GongHaitao FanTeng ZhangYang Zhou

Published in: BMC biology (2022)

Our results point to a key role of sphingosine in the disruption of spermatogenesis in prediabetic sheep and suggest it could be a useful disease marker; furthermore, melatonin represents a potential prebiotic agent for the treatment of male infertility caused by prediabetes.

Keyphrases

oxidative stress
endoplasmic reticulum stress
cell death
cell cycle arrest
risk assessment
polycystic ovary syndrome
cell proliferation
skeletal muscle