Login / Signup

ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells.

Cecilia BergonziniAlessandro GregoriTessa M S HagensVera E van der NoordBob van de WaterAnnelien J M ZweemerBircan CobanMjriam CapulaGiulia MantiniAsia BottoFrancesco FinamoreIngrid GarajovaLiam A McDonnellThomas SchmidtElisa GiovannettiErik H J Danen
Published in: Journal of experimental & clinical cancer research : CR (2024)
Upregulation of ABCB1 through locus amplification represents a novel, conserved mechanism of PDAC paclitaxel resistance. Kinase inhibitors identified in this study can be further (pre) clinically explored as therapeutic strategies to overcome paclitaxel resistance in PDAC.
Keyphrases
  • cell proliferation
  • transcription factor
  • nucleic acid
  • signaling pathway
  • chemotherapy induced
  • label free