Convolutional Neural Network Analysis of Two-Dimensional Hyperfine Sublevel Correlation Electron Paramagnetic Resonance Spectra.
Alexander T TaguchiEthan D EvansSergei A DikanovRobert G GriffinPublished in: The journal of physical chemistry letters (2019)
A machine learning approach is presented for analyzing complex two-dimensional hyperfine sublevel correlation electron paramagnetic resonance (HYSCORE EPR) spectra with the proficiency of an expert spectroscopist. The computer vision algorithm requires no training on experimental data; rather, all of the spin physics required to interpret the spectra are learned from simulations alone. This approach is therefore applicable even when insufficient experimental data exist to train the algorithm. The neural network is demonstrated to be capable of utilizing the full information content of two-dimensional 14N HYSCORE spectra to predict the magnetic coupling parameters and their underlying probability distributions that were previously inaccessible. The predicted hyperfine ( a, T) and 14N quadrupole ( K, η) coupling constants deviate from the previous manual analyses of the experimental spectra on average by 0.11 MHz, 0.09 MHz, 0.19 MHz, and 0.09, respectively.
Keyphrases
- density functional theory
- machine learning
- neural network
- deep learning
- convolutional neural network
- big data
- molecular dynamics
- room temperature
- artificial intelligence
- electronic health record
- energy transfer
- mass spectrometry
- high performance liquid chromatography
- clinical practice
- single molecule
- electron transfer
- ms ms
- solid phase extraction