Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion.
Leticia Serrano-OviedoMarta Ortega-MuelasJesús García-CanoMaría Ll ValeroFrancisco J CimasRaquel Pascual-SerraDiego M Fernandez-ArocaOlga RocheMaría J Ruiz-HidalgoBorja BelandiaJosé M Giménez-BachsAntonio S Salinas-SánchezRicardo Sanchez-PrietoPublished in: PloS one (2018)
The present report demonstrates that Sorafenib exerts its toxic effect through the induction of autophagy in an Akt-dependent fashion without the implication of Mitogen Activated Protein Kinase. Therefore, our data discard the use of inhibitors of the RAF-MEK-ERK1/2 signalling pathway in RCC and support the use of pro-autophagic compounds, opening new therapeutic opportunities for Renal Cell Carcinoma.