An integrated analysis of bile acid metabolism in humans with severe obesity.
Ömrüm AydinAnnika WahlströmPatrick A de JongeAbraham S MeijnikmanWilhelm SjölandLisa OlssonMarcus StahlmanMarcus C de GoffauStijn OonkSjoerd C BruinYair I Z AchermanHanns-Ulrich MarschallVictor E A GerdesMax NieuwdorpFredrik BäckhedAlbert K GroenPublished in: Hepatology (Baltimore, Md.) (2024)
Characterization of the portal BA composition in relation to peripheral and fecal BA increased insight into the dynamics of BA metabolism in individuals with obesity. Peripheral BA composition was much more diverse due to microbial metabolism. About 24% of the portal samples was surprisingly low in total BA; the underlying mechanism requires further exploration.