A Study on Curcumol Influencing Proliferation and Apoptosis of Hepatocellular Carcinoma Cells through DJ-1/PTEN/PI3K/AKT Pathway.

Rongzhen ZhangLu ZhongKewei SunJiao LiuQianna WangDewen MaoRongrong Liu Fuli Long

Published in: BioMed research international (2022)

Curcumol can regulate DJ-1, PTEN, PI3K, and AKT signal transduction pathways, inhibit cell proliferation, and cause a significant increase in the proportion of cell apoptosis, and the pharmacodynamic effect of curcumol is dependent on the time and dose of action.

Keyphrases

cell proliferation
pi k akt
cell cycle arrest
signaling pathway
cell cycle
oxidative stress
endoplasmic reticulum stress
cell death