Systemic administration of ivabradine, a hyperpolarization-activated cyclic nucleotide-gated channel inhibitor, blocks spontaneous absence seizures.
Yasmine IaconeTatiana P MoraisFrançois DavidFrancis DelicataJoanna SandleTimea RaffaiHarri Rheinallt ParriJohan Juhl WeisserChristoffer BundgaardIb Vestergaard KleweGábor TamásMorten Skøtt ThomsenVincenzo CrunelliMagor L LőrinczPublished in: Epilepsia (2021)
These results provide the first demonstration of the antiabsence action of a systemically administered HCN channel blocker, indicating the potential of this class of drugs as a novel therapeutic avenue for ASs.