In vitro evaluation of FL118 and 9-Q20 cytotoxicity and cellular uptake in 2D and 3D different cell models.
Qi WengLeilei ZhouLihua XiaYixin ZhengXiangli ZhangFengzhi LiQingYong LiPublished in: Cancer chemotherapy and pharmacology (2019)
The 3D cell models provided more potency information on the process of cellular uptake of CPT, FL118, and 9-Q20, which more objectively reflected the drug sensitivity and drug resistance in vivo compared with the 2D cell models.