Direct Intramolecular Aminoboration of Allenes.
Chun-Hua YangMeng HanWenyan LiNingning ZhuZhenzhen SunJunjie WangZhantao YangYue-Ming LiPublished in: Organic letters (2020)
Direct intramolecular aminoboration of sulfonamidoallenes was realized using BCl3 as a boron source. The reactions benefited from the interaction between BCl3 and sulfonamides and provided a variety of borylvinyl heterocycles in good isolated yields. When chiral substrates were involved in the reactions, high stereoselectivity was observed, as can be ascertained by single-crystal X-ray diffraction experiments. Derivatization of the thus-obtained borylvinyl compounds proceeded readily, and different functionalities could be obtained via oxidation, halogenation, and Suzuki coupling reactions.
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