High level extracellular production of recombinant human interferon alpha 2b in glycoengineered Pichia pastoris: culture medium optimization, high cell density cultivation and biological characterization.
S KatlaB KarmakarS R R TadiN MohanB AnandU PalSenthilkumar SivaprakasamPublished in: Journal of applied microbiology (2019)
DoE-based medium optimization strategy significantly improved huIFNα2b production. The antiproliferative activity of huIFNα2b substantiates its potential scope for application in cancer therapy.