Chemical control of phase separation in DNA solutions.

Published in: Chemical communications (Cambridge, England) (2023)

We designed a series of DNA sequences comprising a trinucleotide repeat segment and a small molecule-binding aptamer. Optimization of the DNA sequences and reaction conditions enabled chemical control of phase separation of DNA condensates. Our results demonstrate a new strategy to regulate biomolecular phase transition.

Keyphrases

circulating tumor
cell free
small molecule
single molecule
nucleic acid
gold nanoparticles