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CREB-dependent LPA-induced signaling initiates a pro-fibrotic feedback loop between small airway basal cells and fibroblasts.

Shyam NathanHaijun ZhangMirko AndreoliPhilip L LeopoldRonald G Crystal
Published in: Respiratory research (2021)
Inhibition of CREB signaling may represent a novel target for alleviating the LPA-induced pro-fibrotic feedback loop between SAE BC and NHLF.
Keyphrases
  • high glucose
  • diabetic rats
  • induced apoptosis
  • idiopathic pulmonary fibrosis
  • drug induced
  • transcription factor
  • anti inflammatory
  • oxidative stress
  • endothelial cells