Brain structure, working memory and response inhibition in childhood leukemia survivors.
Ellen van der PlasRussell J SchacharJohann K HitzlerJennifer CrosbieSharon L GugerBrenda J SpieglerShinya ItoBrian J NiemanPublished in: Brain and behavior (2016)
Compared with controls, a reduction in volume across brain regions and tissue types, was detectable in ALL survivors years after completion of therapy. These structural alterations were correlated with neurocognitive performance, particularly in working memory. Confirming these observations in a larger, more representative sample of the population is necessary. Additionally, establishing the time course of these changes-and the treatment, genetic, and environmental factors that influence them-may provide opportunities to identify at-risk patients, inform the design of treatment modifications, and minimize adverse cognitive outcomes.
Keyphrases
- working memory
- transcranial direct current stimulation
- attention deficit hyperactivity disorder
- end stage renal disease
- young adults
- chronic kidney disease
- white matter
- emergency department
- type diabetes
- bone marrow
- acute myeloid leukemia
- combination therapy
- multiple sclerosis
- prognostic factors
- stem cells
- gene expression
- genome wide
- bipolar disorder
- blood brain barrier
- electronic health record
- subarachnoid hemorrhage
- weight loss