Optimising the selection of candidates for neoadjuvant chemotherapy amongst patients with node-positive penile squamous cell carcinoma.

Marco BandiniMaarten AlbersenJuan J Chipollini Filippo Pederzoli Yao ZhuDing-Wei YeAntonio A OrnellasNick WatkinMichael AgerOliver W HakenbergAxel HeidenreichDaniele RaggiMario CatanzaroFriederike HaidlElio Mazzone Laura MarandinoAlberto BrigantiFrancesco MontorsiMounsif AziziPhilippe E SpiessAndrea Necchi

Published in: BJU international (2020)

Patients with pSCC with cN3 or cN2 and inguinal and pelvic 18F-FDG-PET/CT scan detected disease had higher 24-month OM rates according to our regression-tree model. NAC was associated with improved OS only in these subgroups of patients. Our novel decision model may help to stratify cN+ patients, and identify those who most likely will benefit from NAC prior to radical surgical resection.

Keyphrases

neoadjuvant chemotherapy
squamous cell carcinoma
end stage renal disease
ejection fraction
newly diagnosed
lymph node metastasis
peritoneal dialysis
prostate cancer
locally advanced
patient reported outcomes
early stage
patient reported
sentinel lymph node
radical prostatectomy