Retrospective pharmacogenetic study of psoriasis highlights the role of KLK7 in TNF signaling.
Haihan ZhangMatthew T PatrickTrilokraj TejasviMrinal K SarkarRachael WasikowskiPhilip E StuartQinmengge LiXianying XingJohn J VoorheesNicole L WardKevin HeXiang ZhouJohann E GudjonssonRajan P NairJames T ElderLam C TsoiPublished in: The British journal of dermatology (2023)
Our study implicates the genetic regulation of cytokine responses in predicting clinical drug response and supports the association between pharmacogenetic loci and anti-TNF response, as shown here for KLK7.