Proposition of a novel animal model of systemic sclerosis induced by type V collagen in C57BL/6 mice that reproduces fibrosis, vasculopathy and autoimmunity.
Walcy Rosolia TeodoroZelita Aparecida de Jesus QueirozLais Araujo Dos SantosSergio CatanoziAntonio Dos Santos FilhoCleonice BuenoMargarete B G VendraminiSandra de Morais FernezlianEsmeralda M EherPercival D Sampaio-BarrosSandra Gofinet PasotoFernanda Degobbi T Q S LopesAna Paula Pereira VelosaVera Luiza CapelozziPublished in: Arthritis research & therapy (2019)
We demonstrated that cutaneous, vascular, and pulmonary remodeling are mimicked in the Col V-induced SSc mouse model, which thus represents a suitable preclinical model to study the mechanisms and therapeutic approaches for SSc.