Sputum transcriptomics implicates increased p38 signalling activity in severe asthma.
Katherine Joanne BainesMichael FrickerVanessa Marie McDonaldJodie Louise SimpsonLisa G WoodPeter A B WarkHeather E MacdonaldAndrew ReidPeter G GibsonPublished in: Respirology (Carlton, Vic.) (2019)
Severe asthma is associated with substantial differences in sputum gene expression that underlie unique cellular mechanisms. The p38 signalling pathway may be important in the pathogenesis of severe asthma, and future investigations into p38 inhibition are warranted as a 'non-Th2' therapeutic option.