Use of therapeutic drug monitoring to characterize cefepime-related neurotoxicity.

Veena VenugopalanDanielle CasausLeonie KainzCara N SlatonNatalie HurstMaria BruzzoneCalvin HuGabriel SwordKartikeya CherabuddiNicole IovineJiajun LiuMarc H ScheetzNathaniel RhodesNicole MaranchickCharles A PeloquinKenneth KlinkerMohammad H Alshaer

Published in: Pharmacotherapy (2022)

Cefepime should be used cautiously in hospitalized patients with renal dysfunction due to the risk of neurotoxicity. Dose optimization utilizing TDM early in cefepime treatment may minimize adverse effects and improve patient safety.

Keyphrases

patient safety
quality improvement
oxidative stress
replacement therapy
drug induced