Prion peptide-mediated calcium level alteration governs neuronal cell damage through AMPK-autophagy flux.

Published in: Cell communication and signaling : CCS (2020)

Our data demonstrated that prion peptide-mediated calcium inflow plays a pivotal role in prion peptide-induced autophagic cell death, and reduction in AMPK activity in neurons. Altogether, our results suggest that calcium influx might play a critical role in neurodegenerative diseases, including prion diseases. Video Abstract.

Keyphrases

cell death
skeletal muscle
oxidative stress
cell cycle arrest
single cell
high glucose
signaling pathway
cell therapy
protein kinase
big data
machine learning
endoplasmic reticulum stress
drug induced
cerebral ischemia
bone marrow
stress induced