The NHS England 100,000 Genomes Project: feasibility and utility of centralised genome sequencing for children with cancer.
Jamie TrotmanRuth ArmstrongHelen FirthClaire TrayersJames WatkinsKieren AllinsonThomas S JacquesJames C NicholsonGladstone A A Burkenull nullSam BehjatiMatthew J MurrayCatherine E HookPatrick TarpeyPublished in: British journal of cancer (2022)
Our findings demonstrate the feasibility and clinical value of centralised WGS for children with cancer. WGS offered additional clinical value, especially in diagnostic terms. However, our experience highlights the need for local expertise in scrutinising and clinically interpreting centrally derived variant calls for individual children.