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Cellular dosimetry of 197Hg, 197mHg and 111In: comparison of dose deposition and identification of the cell and nuclear membrane as important targets.

Zhongli CaiNoor Al-SadenConstantine J GeorgiouRaymond M Reilly
Published in: International journal of radiation biology (2020)
Cellular S-values were reliably calculated with MCNP6. 197Hg and 197mHg deposit two-fold more doses than 111In at the subcellular scale. All AE emitters deposit a higher self-dose in the CM and NM than in the N, which warrants studies on the effects of targeting the CM and NM by AE emitters.
Keyphrases
  • light emitting
  • photodynamic therapy
  • fluorescent probe
  • single cell
  • cell therapy
  • living cells
  • aqueous solution
  • cancer therapy
  • stem cells
  • case control
  • drug delivery